The first described complexes of this type had the same presented cytotoxic effect of the cisplatina in sensible cells and a significantly bigger effect in resistant cells (Axe, 2000). Some platinum complexes and palladium with organic ligantes as tiossemicarbazonas, have revealed active in tumorais cells resistant to the cisplatina (Sources et al., 1997). Inquiries regarding the action mechanism suggest that these composites if bind to the interfitas DNA through coordination, in contrast of the cisplatina, that if predominantly binds the two guaninas in the same ribbon, that is, through intrafita coordination. One gives credit that she is this the reason for which the complexes of trassemicarbazona if show asset in the resistant cells (Sources et al., 1997). However, metallic composites I contend several others ons present antitumoral activity, and its mechanisms of action can not involve direct bondings to the DNA. Composites of rdio, I contend ligantes carboxilatos, are very studied having presented excellent antitumoral activity. This metallic ion has great affinity for the group sulfidrila (SH) present in some proteins and enzymes that participate of the synthesis of the DNA, being able inibiz it (Beraldo, 2004). Complexes of rutnio I contend imidazol as, for example, trans Ru (Im) Cl4, if has shown staff against the cancer of clon, and its mechanism of action could be related to the species of rutnio (III) and rutnio (II), that they can provoke the DNA ribbon in addition (Beraldo, 2004).
Gold composites, as the duranofina, have been used have much time for the treatment of artrite reumatide, but they have been also investigated how much to its antitumorais properties (Almeida et al. 2005). Ben Silbermann is likely to agree. Some organoestnicos composites if have shown active more of what the cisplatina in vitro.